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[(2)-8.44184(0)6.51233(0)6.51233(5)-8.44184(\))4.00871(. 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)-4.22046(C)-5.93822(h)-8.44093(o)21.4674(i)-6.12989(c)-4.62572(e)10.3285(s)0.189848( )-4.22046(A)19.1527(c)-4.62572(t)-6.12989( )-4.22046(o)6.51324(f)4.00871( )250]TJ [(s)2.71321(i)0.356235(t)0.356235(e)-2.64421(s)2.71284( )-124.215(f)7.07018(o)-7.00166(r)-5.00129( )-112.144(b)-7.00166(i)0.356603(o)-19.0731(m)17.4979(e)-2.64432(d)-7.00166(i)0.356603(c)-2.64432(a)-2.64358(l)0.356603( )-112.144(i)0.356603(n)-7(f)7.07018(o)-7(r)-17.0728(m)17.4971(a)-2.64358(t)-11.7149(i)-11.7149(c)-2.64358(s)2.71284( )-112.144(r)-5.00129(e)-2.64358(s)2.71431(e)-2.64358(a)-2.64358(r)-5.00129(c)-2.64358(h)5.07055( )-112.144(i)-11.7149(n)5.07055( )-112.144(t)0.356603(h)5.07055(e)-2.64358( )-124.216(U)-2.28992(n)]TJ )-3.5012( )-51.7871(T)-16.7162(h)5.06907(e)-2.64358( )-51.7871(U)-14.3584(n)5.06907(i)0.356603(t)0.356603(e)-2.64653(d)-7.00239( )-51.7871(K)-2.28698(i)-11.7178(n)-7.00239(g)5.06907(d)-7.00239(o)-19.0739(m)17.5001( )-51.7871(i)]TJ 209.684 0 Td [(h)5.06907(a)-2.64653(r)-4.99834(i)-11.7178(n)5.06907(g)-7.00239( )250]TJ )-3.50077( )-196.645(M)-4.29103(e)-2.64653(a)-2.64653(s)]TJ [(p)-7.00239(i)0.356603(d)-7.00154( )-51.7871(r)-5.00129(e)-2.64358(s)2.71431(p)-7.00239(o)5.06907(n)5.06907(s)2.71431(e)-14.715( )250]TJ [(e)-2.64653(a)-2.64653(r)-4.99834(c)-2.64653(h)5.06907(e)-2.64653(r)-17.0698(s)2.71136( )-88.0014(c)-2.64653(a)-2.64653(n)-7.00239( )250]TJ [(l)0.356603(o)-19.0739(w)9.78449( )-160.43(r)-17.0728(e)-2.64358(-)333]TJ 200.306 0 Td ( )Tj [(d)-7.00239( )-172.502(t)0.353656(o)-7.00239( )-172.502(s)2.71136(u)-7.00154(p)-7.00239(-)333.003]TJ [(p)-7.00166(a)-2.64432(t)0.356235(i)0.356235(e)-2.64432(n)5.06981(t)0.356301(,)-3.50046( )-305.287(i)0.356603(n)5.06981(c)-2.64432(l)-11.7149(u)5.06981(d)-7.00166(i)0.356603(n)-7.00166(g)5.06993( )-305.287(a)-2.64358( )-305.288(f)7.07018(u)-7(l)0.356603(l)0.356603( )-305.287(a)-2.64358(c)-2.64358(c)-2.64358(o)-7(u)5.07055(n)5.07055(t)0.356603( )-305.287(o)-7(f)7.07018( 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)-3.5012( )-184.573(I)-5.00129(n)5.07055( )-184.573(2)-7(0)-7(0)-7(6)5.07055(,)-3.5012( )-184.573(i)0.356603(n)5.07055( )-184.573(r)-5.00129(e)-2.64358(s)2.71431(p)-7.00239(o)-7.00239(n)]TJ 204.394 0 Td 0.998075 0 0 1 374.52 560.28 Tm [(u)5.06907(r)-5.00129(g)5.06907(e)-2.64358(d)-7.00239( )-39.7156(m)5.42568(e)-14.715(m)17.4971(b)-7.00239(e)-2.64358(r)-5.00129( )-27.6441(s)2.71431(t)0.356603(a)-14.715(t)0.356603(e)-2.64421(s)2.71431( )-27.6441(t)0.356603(o)-7.00239( )-27.6441(i)-11.7149(m)17.4971(p)-19.0739(l)0.356603(e)-14.715(m)5.42568(e)-2.64358(n)-7.00239(t)0.356603( )-39.7156(�)9.42725(n)5.06907(a)-2.64358(t)-11.7149(i)0.356603(o)-7.00239(n)5.06907(a)-2.64358(l)0.353656( )-27.6441(e)-2.64653(l)0.353656(e)-2.64653(c)-2.64653(t)0.353646(r)-4.99834(o)-7.00239(n)]TJ 171.089 0 Td [( )-341.502(o)-7.00239(f)7.07018( )250]TJ 230.244 0 Td [( )-39.7156(s)-9.3601(u)5.06907(p)-7.00239(p)-7.00239(o)-7.00239(r)-4.99834(t)0.353656( )-39.7156(s)14.7828(y)5.06993(s)-9.3601(-)333.003]TJ 200.667 0 Td [(r)-5.00129(e)-2.64358(s)2.71431(e)-2.64358(a)-2.64358(r)-5.00129(c)-2.64358(h)5.06907(? [(e)-2.64358(r)-5.00129(. [(l)0.356603(o)-7.00239(g)5.06907(i)-11.7149(c)-2.64358(a)-2.64063(l)12.4281( )250]TJ [(n)5.06907(e)-14.715(w)9.78449( )-136.287(t)0.356603(r)-5.00129(e)-2.64421(a)-2.64358(t)-11.7149(m)5.42568(e)-2.64358(n)5.06907(t)-11.7149(s)2.71431( )-136.287(a)-2.64358(n)5.06907(d)-7.00239( )-136.287(b)-7.00239(e)-2.64358(t)0.356603(t)0.356603(e)-2.64358(r)-5.00129( )-136.287(u)-7.00239(n)-7.00239(d)-7.00239(e)-2.64358(r)-5.00129(s)2.71431(t)0.356603(a)-2.64358(n)5.06907(d)-7.00239( )-136.287(i)0.356603(l)0.356603(l)0.356603(n)5.06907(e)-14.715(s)2.71136(s)2.71136(e)-14.718(s)2.71136(. [(r)-5.00129(c)-2.64358(h)5.06993(. )8.57101(5)-7.00166( )-124.215(m)17.4979(i)-11.7149(l)0.356603(l)0.356603(i)0.356603(o)-7.00166(n)5.06981(. [(s)2.71321(i)-11.7152(m)17.4979(p)-7.00166(l)-11.7149(y)5.06981( )-257.001(m)17.4979(a)-14.7158(k)5.06981(i)-11.7149(n)-7.00166(g)5.07055( )-244.931(a)-2.64432(l)0.356603(l)0.356603( )-244.93(p)-7(a)-2.64358(t)0.356603(i)0.356603(e)-2.64358(n)5.07055(t)0.356603( )-244.93(d)-7(a)-2.64358(t)0.356603(a)-2.64358( )-244.93(a)-2.64358(c)-2.64358(c)-2.64358(e)-2.64358(s)2.71284(s)2.71284(i)0.356603(b)-7(l)0.356603(e)-2.64421( )-244.93(f)7.07018(o)-7(r)-5.00129( )-244.93(r)-5.00129(e)-2.64358(s)2.71431(e)-2.64358(a)]TJ [(s)2.71284(e)-2.64358(t)0.356603(s)2.71431(. [(h)-7.00239( )-184.573(t)0.356603(o)-7.00239( )250]TJ 217.379 0 Td 10.0995 -13.2 Td [(H)4.19856( )-4.22046(R)-5.9364(o)6.51324(a)-4.62206(d)-8.44093(m)0.379696(a)-4.62206(p)6.51324( )-4.22046(f)4.00871(o)6.51324(r)4.00871( )-4.22046(M)-8.25108(e)10.3321(d)6.51324(i)8.82792(c)-4.62206(a)-4.62206(l)8.82792( )250]TJ In 1966, Henry Beecher's article, ‘Ethics and Clinical Research,’ in the New England Journal of Medicine reported 22 examples of medical research that involved suboptimal ethical treatment of human subjects . 207.52 0 Td [(c)-2.64358(a)-2.64358(l)0.356603( )-184.573(i)-11.7152(n)5.06907(-)333]TJ -213.532 -13.2 Td [(s)2.71431(e)-2.64358(a)-2.64358(r)-5.00129(c)-2.64358(h)5.06907( )-172.502(i)0.356603(n)-7.00239(v)5.06907(o)-7.00239(l)0.356603(v)5.06907(e)-2.64358( )-172.502(a)-14.715(n)5.06907( )-172.502(I)-5.00129(T)-4.64468( )-172.501(o)-7.00239(r)7.07018( 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)-51.7856(p)-7.00166(u)5.06981(b)-7.00166(l)0.35513(i)0.356603(c)-14.7157(-)7.07018(h)5.07055(e)-2.64358(a)-2.64358(l)-11.7149(t)0.356603(h)-7( )-63.8585(e)-14.715(m)17.4971(e)-2.64358(r)-5.00129(g)5.07055(e)-14.715(n)5.07055(c)-2.64358(i)0.356603(e)-2.64358(s)2.71311(�)-14.715( )-51.7871([)-5.00129(8)-7(])-5.00129(. -213.051 -13.2 Td -208.722 -13.2 Td [(h)5.06981(e)-2.64432(a)-2.64432(l)0.356603(t)-11.7149(h)5.06981( )-112.144(c)-2.64432(a)-2.64432(r)-5.00129(e)-2.64432( )-124.215(f)7.07018(r)-5.00129(o)-19.0731(m)17.4979( )-112.144(b)-7.00166(a)-2.64358(s)2.71284(i)0.356603(c)-14.715( )-112.144(r)-5.00129(e)-2.64358(s)2.71284(e)-2.64358(a)-2.64358(r)-17.0728(c)-2.64358(h)5.07055( )-112.144(t)0.356603(o)-7( )-112.144(c)-2.64358(a)-2.64358(r)-5.00129(e)-2.64358( )-112.144(d)-7(e)-2.64358(l)0.356603(i)-11.7149(v)5.07055(e)-2.64358(r)-17.0728(y)17.142( )-112.144(a)-14.715(n)]TJ 207.4 0 Td [(H)-2.28698(o)-19.0739(w)21.856( )-100.073(a)-2.64358(r)-5.00129(e)-2.64358( )-100.072(t)-11.7149(h)5.06907(e)-2.64358( )-100.073(U)-14.3584(n)5.06907(i)0.356603(t)0.356603(e)-2.64358(d)-7.00239( )-100.073(S)-11.3583(t)0.356603(a)-2.64358(t)0.356603(e)-2.64358(s)2.71431( )-100.073(a)-14.715(n)-7.00239(d)-7.00239( )-100.073(t)0.356603(h)5.06907(e)-2.64358( )-100.073(U)-14.3584(n)5.06907(i)0.356603(t)0.356603(e)-2.64358(d)-7.00239( )-100.073(K)-2.28698(i)-11.7178(n)-7.00239(g)5.06907(d)-7.00239(o)-19.0739(m)17.5001( )-100.072(i)-11.7178(n)]TJ [(a)-14.7158(w)21.8552(a)-14.7158(y)17.1413( )-257.001(f)7.07018(r)-5.00129(o)-19.0731(m)17.4979( )-244.93(p)-7.00166(a)-2.64432(p)-7(e)-2.64495(r)-5.00129( )-257.001(m)17.4971(e)-2.64358(d)-7(i)0.356603(c)-2.64358(a)-2.64358(l)0.356603( )-244.93(r)-5.00129(e)-2.64358(c)-2.64358(o)-7(r)-5.00129(d)-7(s)2.71284(,)-3.5012( )-244.93(t)0.356603(h)5.07055(i)0.356603(s)2.71284( )-244.93(d)-7(a)-2.64358(t)0.356603(a)-2.64358( )-244.93(i)0.356603(s)2.71284( )-244.93(i)0.356603(n)5.06907(c)-2.64358(r)-5.00129(e)]TJ -217.018 -13.2 Td -215.816 -13.2 Td -199.945 -13.2 Td 228.801 0 Td )-15.5727( )]TJ 214.013 0 Td endobj [(f)7.07055(o)-7.00166(r)-5( )-389.788(t)0.356603(h)5.06981(i)0.356603(s)2.71284( )-389.787(r)-5.00129(e)-2.64432(s)2.71284(e)-2.64432(a)-2.64432(r)-5(c)-14.7158(h)5.06981( )-401.86(w)9.78302(i)0.356603(l)0.356603(l)0.356603( )-389.788(c)-2.64358(o)-19.0724(m)5.42568(e)-14.715( )-389.787(b)-7(o)-7(t)0.356603(h)5.07055( )-389.788(f)7.07018(r)-5.00129(o)-19.0724(m)17.4971( )-389.788(M)-4.28808(R)-9.00202(C)3.06944( )-389.788(a)-2.64358(n)5.06907(d)-7.00239( )-389.788(N)-2.28698(I)-17.0728(H)-2.28698(R)3.07386( )]TJ [(s)2.71431( )-172.502(r)-5.00129(e)-2.64358(s)2.71431(e)-2.64358(a)-2.64358(r)-5.00129(c)-2.64358(h)5.06907(,)-15.5727( )250]TJ [(n)-7.00239( )-148.359(T)-16.7162(e)-2.64358(c)-2.64421(h)5.06907(-)333]TJ -207.159 -13.2 Td [(p)-7.00166(e)-2.64432(r)-5(f)7.07055(o)-7.00166(r)-5.00129(m)17.4979(a)-14.7158(n)5.06981(c)-2.64432(e)-2.64432( )-160.43(c)-2.64432(o)-19.0724(m)17.4979(p)-19.0731(u)5.06907(t)0.356603(i)-11.7149(n)-7(g)5.07055( )-160.43(r)-5.00129(e)-2.64358(s)2.71284(o)-19.0724(u)5.07202(r)-5.00129(c)-2.64358(e)-2.64358(s)2.71284( )-160.43(a)-14.715(n)5.07055(d)-7( )-160.43(t)0.356603(o)-7(o)-7(l)0.356603(s)2.71284( )-172.502(n)5.07055(e)-2.64358(e)-2.64358(d)-7.00239(e)-2.64358(d)-7.00239( )-160.43(t)0.356603(o)]TJ -227.839 -13.32 Td )-3.50077( )]TJ [(m)5.42568(e)-2.64421(d)-7.00239(i)0.356603(c)-2.64358(a)-2.64358(l)0.356603( )-39.7156(i)0.356603(n)-7.00239(f)7.07018(o)-7.00239(r)-17.0728(m)17.4971(a)-2.64358(t)0.356603(i)0.356603(c)-14.715(s)2.71431( )-39.7152(i)0.356603(s)2.71431( )-39.7156(t)0.356603(h)5.06907(e)-2.64358( )-39.7156(u)-7.00239(s)2.71431(e)-14.715( )-39.7156(o)-7.00239(f)7.07018( )-39.7152(c)-2.64358(l)0.356603(i)0.356603(n)5.06907(i)0.356603(c)-2.64358(a)-2.64358(l)0.356603( )-39.7152(d)-7.00239(e)-2.64358(c)-2.64653(i)0.353656(s)2.71136(i)0.353656(o)-7.00239(n)]TJ [(p)-7.00166(r)-5(o)-7.00166(p)5.06981(o)-7.00166(s)2.71284(e)-2.64432(d)-7.00166( )-160.43(a)-2.64432(n)5.06981( )-160.43(i)0.356603(n)5.06981(c)-2.64432(r)-5.00129(e)-2.64432(a)-2.64358(s)2.71284(e)-2.64358( )-160.43(o)-7(f)7.07018( )-160.43($)-7(2)-7(. 10.0995 -13.32 Td /R8 9.96 Tf -193.212 -13.2 Td [(C)-5.9364(a)-4.62572(t)-6.12989(e)10.3285(g)6.51324(o)6.51324(r)4.00871(i)-6.12989(e)10.3285(s)0.189848( )-4.22046(\()4.00871(R)-5.9364(C)-5.9364(D)4.19856(C)-5.9364(\))18.9629(�)-4.62572( )-4.22046(N)4.19856(a)10.3285(t)-6.12989(i)-6.12989(o)21.4674(n)-8.44093(a)-4.62572(l)8.82427( )-4.22046(I)33.917(n)-8.44093(s)0.189848(t)-6.12989(i)-6.12989(t)-6.12989(u)6.51324(t)8.82427(e)10.3285(s)0.189848( )-4.22046(o)6.51324(f)4.00871( )-4.22046(H)4.19856(e)10.3285(a)-4.62572(l)8.82427(t)-6.12989(h)-8.44093( )-4.22046(\()4.00871(M)]TJ 199.585 0 Td [(t)0.356235(i)0.356235(n)-7.00166(g)5.06981( )-124.215(a)-2.64432(n)5.06981(d)-7.00166( )-124.215(I)-5.00129(n)5.06981(f)7.07018(o)-7.00166(r)-17.0728(m)17.4986(a)-14.7158(t)0.356603(i)0.356603(c)-2.64505(s)2.71284( )-124.216(O)-14.3599(f)7.07018(f)-5.00129(i)0.356603(c)-2.64358(e)-2.64358( )-124.216(w)9.78449(i)0.356603(t)-11.7149(h)5.07055(i)-11.7149(n)5.07055( )-124.216(i)0.356603(t)0.356603(s)2.71284( )-124.216(C)3.06944(e)-14.715(n)5.07055(t)0.356603(e)-2.64358(r)-5.00129( )-124.216(f)7.07018(o)-7(r)-5.00129( )-124.216(I)]TJ [(M)-4.28808(u)5.06981(c)-2.64432(h)5.06981( )-51.7866(m)5.42641(e)-2.64432(d)-7.00166(i)0.356603(c)-2.64432(a)-2.64432(l)0.356603( )-39.7152(r)-5.00129(e)-2.64358(s)2.71284(e)-2.64358(a)-2.64358(r)-5.00129(c)-14.715(h)5.07055( )-39.7156(d)-7(a)-2.64358(t)0.356603(a)-2.64358( )-39.7156(i)0.356603(s)2.71284( )-39.7156(n)5.07055(o)-7(t)0.356603( )-39.7156(a)-2.64358(c)-2.64358(c)-2.64358(e)-2.64358(s)-9.35863(s)2.71284(i)0.356603(b)-7(l)0.356603(e)-2.64358( )-39.7141(e)-2.64358(l)0.353656(e)-2.64358(c)-2.64358(t)0.356301(r)]TJ 2 Study design is the procedure under which a study is carried out Study design is the procedure under which a study is . [(i)0.356603(n)-7.00239(f)7.07018(o)-7.00239(r)-17.0728(m)17.4971(a)-2.64358(t)0.356603(i)0.356603(c)-14.715(s)2.71431(,)-3.5012( )-15.5727(b)-7.00239(i)0.356603(o)-7.00239(i)0.356603(n)-7.00239(f)7.07018(o)-7.00239(r)-17.0728(m)17.4971(a)-2.64358(t)0.356603(i)0.356603(c)-14.715(s)2.71431( )-15.5727(a)-2.64358(n)-7.00239(d)-7.00239( )-15.5727(c)-2.64358(o)-7.00239(m)17.4971(p)-19.0739(u)5.06907(t)0.356603(a)-2.64358(t)0.356603(i)0.356603(o)-7.00239(n)5.06907(a)-14.718(l)0.353656( )-15.5727(b)-7.00239(i)0.353656(o)-7.00239(l)0.353656(o)]TJ Q 165.439 0 Td 213.652 0 Td 4.16667 0 0 4.16667 0 0 cm BT )-3.5012( )-184.573(O)-2.28845(N)-2.28845(I)-5.00129(X)-2.28845( )-184.573(i)0.356603(s)2.71284( )-184.573(a)9.42789( )-184.573(p)-7(o)5.07055(r)-5.00129(t)0.356603(a)-2.64358(l)0.356603( )-184.573(t)0.356603(o)5.06907( )-184.573(v)5.06907(a)]TJ [(m)5.42568(a)-2.64358(k)5.06907(e)-14.715( )-63.8585(t)-11.7149(h)5.06907(e)-2.64358( )-75.93(v)5.06907(a)-2.64358(s)2.71431(t)0.356603( )-63.8585(a)-14.715(m)5.42568(o)-19.0739(u)5.06907(n)5.06907(t)-11.7149( )-63.8585(o)-7.00239(f)7.07018( )-75.93(m)5.42568(e)-2.64358(d)-19.0739(i)0.356603(c)-2.64358(a)-2.64358(l)0.356603( )-63.8585(d)-7.00239(a)-2.64358(t)0.356603(a)-2.64358( )-63.8585(b)-7.00239(e)-2.64358(i)0.356603(n)-7.00239(g)5.06907( )-75.93(g)5.06907(e)-2.64653(n)5.06907(e)-2.64653(r)-4.99834(a)-2.64653(t)0.353656(e)]TJ [(a)-2.64358(v)5.06907(a)-2.64358(i)0.356603(l)0.356603(a)-2.64358(b)-7.00239(l)0.356603(e)-2.64358( )-63.8585(w)9.78449(i)0.356603(t)0.356603(h)5.06907( )-51.7871(a)-2.64358(s)2.71431( )-63.8585(f)7.07018(e)-14.715(w)9.78449( )-51.7871(r)-5.00129(e)-2.64358(s)2.71431(t)0.356603(r)-5.00129(i)0.356603(c)-2.64358(t)0.356603(i)-11.7149(o)-7.00239(n)5.06907(s)2.71431( )-51.7871(a)-2.64358(s)2.71431( )-51.7871(p)-7.00239(o)-7.00239(s)2.71431(s)2.71431(i)0.356603(b)-7.00239(l)0.356603(e)-2.64653( )-51.7871(f)7.07312(o)-7.00239(r)-4.99834( )]TJ )-3.5012( )-15.5727(T)-16.7162(h)5.06907(i)0.356603(s)2.71431( )-15.5722(i)-11.7149(s)2.71431( )-15.5727(n)-7.00239(o)-7.00239(t)0.356603( )250]TJ [(s)2.71431(h)5.06907(a)-2.64358(r)-5.00129(e)-2.64358(d)-7.00239( )-100.073(f)7.07018(o)-7(r)-5.00129( )250]TJ -204.274 -13.32 Td Q [(i)-11.7178(f)-4.99834(f)7.07312(e)-2.64653(r)-4.99834(e)-2.64653(n)5.06907(t)-11.7178( )250]TJ 10.0995 -13.32 Td This format is the division of the paper into "Introduction, Methods, Results and Discussion" -- the traditional IMRD sections of the research paper. [(e)-2.64432(x)5.06981(a)-14.7158(m)17.4979(p)-7.00166(l)0.356603(e)-2.64432(,)-3.50046( )-426.002(a)-14.7158(n)5.06981(a)-2.64432(l)-11.7149(y)17.142(z)-2.64432(i)-11.7149(n)-7.00166(g)5.06907( )-426.002(D)-2.28845(N)-14.3599(A)9.78302( )-426.002(s)-9.35863(e)-2.64211(q)-7(u)5.07055(e)-2.64358(n)5.07055(c)-2.64358(e)-2.64358(s)2.71284( )-426.002(o)-7.00301(r)-5.00129( )-438.074(m)17.4971(o)-7(d)-7(e)-2.64358(l)0.356603(i)0.356603(n)-7.00239(g)5.06907( )-426.002(p)-7.00239(r)-5.00129(o)-7.00239(t)0.356603(e)-2.64358(i)]TJ -215.095 -13.2 Td [(c)-2.64653(h)-7.00239(n)5.06907(i)0.353656(q)-7.00239(u)5.06907(e)-14.718(s)-9.3601( )250]TJ [(S)0.713207(o)-19.0739(m)17.4971(e)-2.64358( )-27.6441(o)-7.00239(f)7.07018( )-27.6441(t)-11.7149(h)5.06907(e)-2.64358( )-27.6441(q)-7.00239(u)5.06907(e)-14.715(s)2.71431(t)0.356603(i)0.356603(o)-7.00239(n)-7.00239(s)2.71431( )-27.6441(t)0.356603(h)-7.00239(i)0.356603(s)2.71431( )-27.6441(p)-7.00239(a)-14.715(p)-7.00239(e)-2.64358(r)-5.00129( )-39.7156(w)21.856(i)0.356603(l)0.356603(l)0.356603( )-27.6441(l)0.356603(o)-7.00239(o)-7.00239(k)5.06907( )-27.6441(a)-2.64653(t)0.353656( )-27.6441(a)-2.64653(r)-4.99834(e)-2.64653( )-27.6441(a)]TJ -212.45 -13.2 Td 201.508 0 Td [(r)-4.99834(e)-2.64653(s)2.71136(e)-2.64653(a)-2.64653(r)-17.0698(c)-2.64653(h)5.06907(. W n [(-)4.00871(O)4.19856(D)4.19855(-)4.00871(0)-8.44093(3)-8.4417(-)4.00871(0)-8.44093(3)6.51324(2)-8.44093(.)10.7337(h)-8.4417(t)-6.12624(m)0.379696(l)8.82791(. Q -220.144 -13.32 Td 210.406 0 Td -194.896 -13.2 Td 213.532 0 Td [(n)5.06907(d)-7.00239( )-124.216(s)-9.35716(y)5.06907(m)-6.64524(p)-7.00239(-)333]TJ 204.033 0 Td 229.522 0 Td 0 G [(t)0.356603(h)5.06907(e)-2.64358( )-3.5012(d)-7.00239(a)-2.64358(t)0.356603(a)-2.64358( )-3.5012(t)0.356603(o)-7.00239( )-3.5012(b)-7.00239(e)-2.64358(t)0.356603(t)0.356603(e)-2.64358(r)-5.00129( )-3.5012(i)0.356603(n)5.06907(f)7.07018(o)-7.00239(r)-17.0728(m)17.4971( )-3.5012(t)-11.7149(h)5.06907(e)-2.64358(i)0.356603(r)-5.00129( )-3.5012(t)-11.7149(r)-5.00129(e)-2.64358(a)-2.64358(t)-11.7149(m)17.4971(e)-2.64358(n)-7.00239(t)0.356603(s)2.71431( )-3.5012(a)-2.64358(n)5.06907(d)-7.00239( )-3.5012(d)-7.00239(i)0.353656(a)-2.64653(g)]TJ [(i)0.353656(c)-2.64653( )-27.6441(p)-7.00239(u)5.06907(b)-7.00239(l)-11.7178(i)0.353656(c)-2.64653(-)]TJ <> [(a)-2.64358(u)-7.00239(t)0.356603(i)0.356603(o)-7.00239(u)5.06907(s)-9.35715( )-112.144(o)-7.00239(f)7.07018( )250]TJ /R8 8.04 Tf -208.602 -13.2 Td 228.44 0 Td -224.593 -13.32 Td [(u)5.06981(s)2.71321(e)-2.64432( )-63.8582(t)-11.7149(h)5.06981(e)-14.7158(m)5.42641( )-63.8578(i)0.356603(n)5.06981( )-75.9296(t)0.356603(h)5.06981(e)-2.64432( )-63.8578(U)-14.3592(n)5.07055(i)0.356603(t)0.356603(e)-2.64358(d)-7( )-63.8585(K)-2.28845(i)-11.7149(n)-7(g)5.07055(d)-7(o)-7(m)17.4971(. [(2)-8.44184(0)6.51233(0)6.51233(5)-8.44184(\))4.00871(. [(l)0.356235(i)0.356235(o)-7.00166(n)5.06981(,)-3.50046( )-39.7149(t)0.356603(h)5.06981(e)-14.7158( )-39.7149(N)-2.28771(I)-5.00129(H)-2.28771( )-39.7149(e)-2.64432(s)2.71357(t)-11.7149(i)-11.7149(m)17.4971(a)-14.715(t)0.356603(e)-2.64358(s)2.71284( )-51.7871(f)-5.00129(u)5.07055(n)5.07055(d)-7(i)-11.7149(n)5.07055(g)5.07202( )-63.8585(w)9.78302(i)0.356603(l)0.356603(l)0.356603( )-39.7156(r)-5.00129(e)-2.64358(a)-2.64358(c)-14.715(h)5.07055( )-39.7156($)-7(9)-7(5)-7(0)-7( )-39.7156(m)5.42568(i)0.356603(l)]TJ -216.177 -13.32 Td [( )250]TJ [(B)-9.00202(e)-2.64432(t)-11.7149(w)21.8552(e)-2.64432(e)-14.7158(n)5.06981( )-244.93(2)-7.00166(0)-7.00166(0)-7.00166(4)-7.00154( )-232.858(a)-2.64358(n)5.07055(d)-7( )-232.859(2)-7(0)-7(0)5.07055(6)-7(,)-3.5012( )-232.859(N)-2.28845(C)3.06944(I)-5.00129(C)3.06944(B)-9.00202( )-232.859(\()-5.00129(n)5.07055(o)-19.0724(w)9.78302( )-244.93(C)3.06944(B)-9.00202(I)-5.00129(I)-5.00129(T)-16.7162(\))-5.00103( )-232.859(p)-7.00239(r)7.07018(o)-7.00239(v)5.06907(i)0.356603(d)-7.00239(e)-2.64358(d)5.06907( )250]TJ 4.16667 0 0 4.16667 0 0 cm BT [( )-75.93(w)21.856(h)-7.00239(i)0.353656(c)-2.64653(h)-7.00239( )250]TJ -214.133 -13.2 Td 211.247 0 Td [(n)5.06907(t)0.356603( )-100.073(m)5.42568(a)-14.715(n)-7.00239(n)-7.00239(e)-2.64358(r)-5.00129(. 53.7436 641.52 Td )-3.50077( )-15.5727(W)-9.64597(h)5.07055(i)0.356603(l)0.356603(e)-2.64358( )-15.5727(a)-2.64358( )-3.5012(p)-7(a)-2.64358(t)0.356603(i)0.356603(e)-2.64358(n)5.07055(t)0.356603( )-15.5727(v)5.07055(i)]TJ ET [(r)-5(a)-2.64432(p)-7.00166(i)0.356235(d)-7.00166( )-112.144(l)0.356603(e)-2.64432(a)-2.64432(r)-5.00129(n)5.06981(i)0.356603(n)5.06981(g)5.06981( )-112.144(n)5.07055(e)-2.64432(t)-23.7863(w)21.8545(o)-7(r)-17.0728(k)5.07055(s)2.71284(,)-3.5012( )-112.144(h)5.07055(e)-2.64358(a)-2.64358(l)-11.7149(t)-11.7149(h)5.07055( )-112.144(c)-2.64358(a)-2.64358(r)-5.00103(e)-2.64358( 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)-4.22046(C)-5.93822(h)-8.44093(o)21.4674(i)-6.12989(c)-4.62572(e)10.3285(s)0.189848( )-4.22046(A)19.1527(c)-4.62572(t)-6.12989( )-4.22046(o)6.51324(f)4.00871( )250]TJ [(s)2.71321(i)0.356235(t)0.356235(e)-2.64421(s)2.71284( )-124.215(f)7.07018(o)-7.00166(r)-5.00129( )-112.144(b)-7.00166(i)0.356603(o)-19.0731(m)17.4979(e)-2.64432(d)-7.00166(i)0.356603(c)-2.64432(a)-2.64358(l)0.356603( )-112.144(i)0.356603(n)-7(f)7.07018(o)-7(r)-17.0728(m)17.4971(a)-2.64358(t)-11.7149(i)-11.7149(c)-2.64358(s)2.71284( )-112.144(r)-5.00129(e)-2.64358(s)2.71431(e)-2.64358(a)-2.64358(r)-5.00129(c)-2.64358(h)5.07055( )-112.144(i)-11.7149(n)5.07055( )-112.144(t)0.356603(h)5.07055(e)-2.64358( )-124.216(U)-2.28992(n)]TJ )-3.5012( )-51.7871(T)-16.7162(h)5.06907(e)-2.64358( )-51.7871(U)-14.3584(n)5.06907(i)0.356603(t)0.356603(e)-2.64653(d)-7.00239( )-51.7871(K)-2.28698(i)-11.7178(n)-7.00239(g)5.06907(d)-7.00239(o)-19.0739(m)17.5001( )-51.7871(i)]TJ 209.684 0 Td [(h)5.06907(a)-2.64653(r)-4.99834(i)-11.7178(n)5.06907(g)-7.00239( )250]TJ )-3.50077( )-196.645(M)-4.29103(e)-2.64653(a)-2.64653(s)]TJ [(p)-7.00239(i)0.356603(d)-7.00154( )-51.7871(r)-5.00129(e)-2.64358(s)2.71431(p)-7.00239(o)5.06907(n)5.06907(s)2.71431(e)-14.715( )250]TJ [(e)-2.64653(a)-2.64653(r)-4.99834(c)-2.64653(h)5.06907(e)-2.64653(r)-17.0698(s)2.71136( )-88.0014(c)-2.64653(a)-2.64653(n)-7.00239( )250]TJ [(l)0.356603(o)-19.0739(w)9.78449( )-160.43(r)-17.0728(e)-2.64358(-)333]TJ 200.306 0 Td ( )Tj [(d)-7.00239( )-172.502(t)0.353656(o)-7.00239( )-172.502(s)2.71136(u)-7.00154(p)-7.00239(-)333.003]TJ [(p)-7.00166(a)-2.64432(t)0.356235(i)0.356235(e)-2.64432(n)5.06981(t)0.356301(,)-3.50046( )-305.287(i)0.356603(n)5.06981(c)-2.64432(l)-11.7149(u)5.06981(d)-7.00166(i)0.356603(n)-7.00166(g)5.06993( )-305.287(a)-2.64358( )-305.288(f)7.07018(u)-7(l)0.356603(l)0.356603( )-305.287(a)-2.64358(c)-2.64358(c)-2.64358(o)-7(u)5.07055(n)5.07055(t)0.356603( )-305.287(o)-7(f)7.07018( 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